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Int J Clin Exp Pathol 2010;3(3):313-318
Case Report
Squamous cell carcinoma and osteosarcoma arising from a dermoid cyst-a case report
and review of literature
Pushpa Allam-Nandyala, Marilyn M. Bui, Jamie T. Caracciolo, Ardeshir Hakam
Department of Graduate Medical Education, Department of Anatomic Pathology, Department of Sarcoma, Department of Women’s Oncology, H.
Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Received December 21, 2009; accepted January 6, 2009; available online January 10, 2009
Abstract: A rare case of multiple malignant tumors (poorly differentiated squamous cell carcinoma and high grade osteosarcoma) arising in
an ovarian dermoid cyst of a 55 year old female is reported. To the best of our knowledge, this is the first well documented example of such an
unusual combination of tumors arising in a dermoid cyst. The osteosarcoma and squamous cell carcinoma appear to arise in the background
of benign teratomatous environment of a dermoid cyst rather than from “pure” mixed mesodermal tumors of the ovary. The tumors did not
appear to have well demarcated boundaries with a junction or close intermingling of both cell types, features less favorable for collision tumor
or carcinosarcoma. Despite extensive surgery with negative surgical margins and combination chemotherapy, the patient had recurrence of the
tumor within four months and she died secondary to septicemia to chemotherapy and bilateral pulmonary emboli shortly after. (IJCEP912006).
Key words: Malignant dermoid, teratoma, osteosarcoma, squamous carcinoma
Full text PDF
Address all correspondence to:
Ardeshir Hakam, MD
Department of Anatomic Pathology
Department of Women’s Oncology
Moffitt Cancer Center
12902 USF Magnolia Drive
Tampa, FL 33612, USA.
Tel: 813-745-1874, Fax: 813-745-1708
E-mail: Ardeshir.Hakam@moffitt.org
Case Report
Squamous cell carcinoma and osteosarcoma arising from a dermoid cyst-a case report
and review of literature
Pushpa Allam-Nandyala, Marilyn M. Bui, Jamie T. Caracciolo, Ardeshir Hakam
Department of Graduate Medical Education, Department of Anatomic Pathology, Department of Sarcoma, Department of Women’s Oncology, H.
Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Received December 21, 2009; accepted January 6, 2009; available online January 10, 2009
Abstract: A rare case of multiple malignant tumors (poorly differentiated squamous cell carcinoma and high grade osteosarcoma) arising in
an ovarian dermoid cyst of a 55 year old female is reported. To the best of our knowledge, this is the first well documented example of such an
unusual combination of tumors arising in a dermoid cyst. The osteosarcoma and squamous cell carcinoma appear to arise in the background
of benign teratomatous environment of a dermoid cyst rather than from “pure” mixed mesodermal tumors of the ovary. The tumors did not
appear to have well demarcated boundaries with a junction or close intermingling of both cell types, features less favorable for collision tumor
or carcinosarcoma. Despite extensive surgery with negative surgical margins and combination chemotherapy, the patient had recurrence of the
tumor within four months and she died secondary to septicemia to chemotherapy and bilateral pulmonary emboli shortly after. (IJCEP912006).
Key words: Malignant dermoid, teratoma, osteosarcoma, squamous carcinoma
Full text PDF
Address all correspondence to:
Ardeshir Hakam, MD
Department of Anatomic Pathology
Department of Women’s Oncology
Moffitt Cancer Center
12902 USF Magnolia Drive
Tampa, FL 33612, USA.
Tel: 813-745-1874, Fax: 813-745-1708
E-mail: Ardeshir.Hakam@moffitt.org
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